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This was evident for women with a first-degree family history of breast cancer (HR=0.68, 95% CI: 0.50-0.93), women without BRCA1 or BRCA2 pathogenic variants (HR=0.71, 95% CI: 0.53-0.95), postmenopausal women (HR=0.63, 95% CI: 0.44-0.89), and for risk of ER+breast cancer (HR=0.63, 95% CI: 0.40-0.98).Adherence to the 2020 ACS Guideline recommendations for BMI, physical activity, and alcohol consumption could reduce breast cancer risk for postmenopausal women and women at increased familial risk. Risk-reducing salpingo-oophorectomy was associated with a reduced risk of breast cancer for BRCA1 and BRCA2 pathogenic variant carriers within 5 years after surgery (hazard ratios [HRs], 0.28 [95% CI,0.10-0.63] and 0.19 [95% CI, 0.06-0.71], respectively), whereas the corresponding HRs were weaker after 5 years postsurgery (HRs, 0.64 [95% CI,0.38-0.97] and 0.99 [95% CI; 0.84-1.00], respectively). These findings warrant intensive surveillance for second breast cancers in women with HR-negative tumors. Clinical guidelines often use predicted lifetime risk from birth to define criteria for making decisions regarding breast cancer screening rather than thresholds based on absolute 5-year risk from current age.We used the Prospective Family Cohort Study of 14,657 women without breast cancer at baseline in which, during a median follow-up of 10years, 482 women were diagnosed with invasive breast cancer. Risk-adapted screening and prevention protocols are underway, with ongoing refinement as genetic knowledge grows. Morra, A., Escala-Garcia, M., Beesley, J., Keeman, R., Canisius, S., Ahearn, T. U., Andrulis, I. L., Anton-Culver, H., Arndt, V., Auer, P. L., Augustinsson, A., Beane Freeman, L. E., Becher, H., Beckmann, M. W., Behrens, S., Bojesen, S. E., Bolla, M. K., Brenner, H., Brning, T., Buys, S. S., Caan, B., Campa, D., Canzian, F., Castelao, J. E., Chang-Claude, J., Chanock, S. J., Cheng, T. D., Clarke, C. L., Colonna, S. V., Couch, F. J., Cox, A., Cross, S. S., Czene, K., Daly, M. B., Dennis, J., Drk, T., Dossus, L., Dunning, A. M., Dwek, M., Eccles, D. M., Ekici, A. Electronic medical records (EMRs) and population-based cancer registries contain information on cancer outcomes and treatment, yet rarely capture information on the timing of metastatic cancer recurrence, which is essential to understand cancer survival outcomes. different epithelial ovarian cancer screening strategies that use CA125 and add HE4 as either Lee, K. L., Janz, N. K., Zikmund-Fisher, B. J., Jagsi, R. n., Wallner, L. P., Kurian, A. W., Katz, S. J., Abrahamse, P. n., Hawley, S. T. Racial/ethnic differences in multiple-gene sequencing results for hereditary cancer risk. Odds of excellent pQoC were lower among the following: college-educated Hispanic women (aOR (CI) = 0.09 (0.02-0.47)) and API women regardless of education (aORs 0.50) vs. college-educated White women, women reporting low and moderate levels of discrimination (aORs 0.44) vs. none, and women reporting any clinician mistrust (aOR (CI) = 0.50 (0.29-0.88)) vs. none. Efforts to enhance physicians' ability to engage in individualized communication around risk are needed. I graduated summa cum laude with a B.Sc. By contrast, VUS results were more frequent among nonwhites, with potential significance for the impact of MGS testing by race/ethnicity.GENETICS in MEDICINE advance online publication, 27 July 2017; doi:10.1038/gim.2017.96. talazoparib (also known as BMN 673) in subjects with locally advanced or metastatic breast View details for Web of Science ID 000268812900007, View details for PubMedCentralID PMC2720990, View details for DOI 10.1200/JCO.2008.16.8310. Nat Fyfe Girlfriend 2023, Age, Height, Wikipedia, Net Worth, John Millman Girlfriend Or Wife In 2023? Other hospital characteristics were not associated with survival.African American women may benefit significantly from breast cancer care in ACS program hospitals; however, most did not receive initial care at such facilities. We extracted individual-level data on chemotherapy administration from the electronic medical records of Kaiser Permanente Northern California (KPNC), a pre-paid integrated healthcare system serving 29 % of the local population. Comprehensive cancer risk assessment is highly relevant to the Precision Medicine Initiative (PMI), and payers' considerations could inform PMI's efforts. All patients underwent comprehensive BRCA1/2 genotyping. Alternatively, those who endorsed more adaptive mindsets (Cancer is Manageable or Cancer can be an Opportunity) reported better HRQOL compared with those who disagreed (all p-values < .05). Our knowledge of the contribution of lifestyle factors to disease prognosis is based primarily on non-Latina Whites and is limited for Latina, African American, and Asian American women. The primary analyses focused on the overall cohort and on women from the general population. Call (512) 324-3440 to schedule an appointment. abnormal breast duct cytology in women with a high inherited breast cancer risk. Price, E. R., Hargreaves, J., Lipson, J. George Kurian lays out future vision of humankind built on social consciousness", "Why Google Cloud's new CEO Thomas Kurian quit Oracle after 22 years", "Oracle Fusion Middleware Wins Two InfoWorld Technology of the Year Awards", "Magic Quadrant for Application Infrastructure for Systematic Application Integration Projects", "Magic Quadrant for Application Infrastructure for Systematic SOA-Style Application Projects", "Magic Quadrant for Shared SOA Interoperability Infrastructure Projects", "Thomas Kurian: Executive Profile & Biography - Businessweek", "2007 JavaOne Conference -General Session Speakers", "Indian American Thomas Kurian is the new CEO of Google Cloud: Here's what you need to know about him", "For Oracle every revolution is an evolution", "Oracle's Software Development Reins in New Hands", "25 highest-paid men - Thomas Kurian (18)", "Oracle Execs, Apple's Tim Cook Among Highest-Paid in Tech", "Top Oracle Software Executive to Take Extended Leave", "Oracle says Kurian has resigned as president three weeks after he left to take time off", "Google Cloud CEO Diane Greene is out, to be replaced by former Oracle exec Thomas Kurian", "Thomas Kurian on his first year as Google Cloud CEO", https://en.wikipedia.org/w/index.php?title=Thomas_Kurian&oldid=1139738920, Short description is different from Wikidata, Wikipedia articles needing clarification from May 2020, Articles with unsourced statements from May 2020, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 16 February 2023, at 17:29. He retired from the Defense Finance and Accounting Service in Columbus, Ohio in 2004. Among LEP subgroups, Spanish speakers were significantly less likely to engage with the patient portal compared with English speakers (estimated difference in monthly rate: OR, 0.43; 95% CI, 0.24 to 0.77).We found that patients with LEP had lower rates of clinical trial engagement and odds of electronic patient portal enrollment. The rate of a variant of uncertain significance (VUS) result was higher in nonwhites than whites (36% vs. 27%; P=2E-4). Research on the communication of genetic test results has focused predominately on non-Hispanic White (NHW) mutation-positive families with high-risk hereditary cancer conditions. View details for Web of Science ID 000341349900011, View details for Web of Science ID 000336894600041, View details for Web of Science ID 000358613202339, View details for DOI 10.1200/jco.2014.32.15_suppl.6580, View details for Web of Science ID 000358613203765. Multiple imputation is a well-established general technique for analyzing data with missing values. The tumor necrosis factor signaling pathway was identified as the top enriched pathway (hypergeometric P < .0001) among genes associated with the image feature. 1. Medicare's recent decision to cover NGTS makes this topic particularly urgent to examine. Receipt of initial care in ACS program hospitals varied by race/ethnicity-highest among non-Latina White patients (45%), and lowest among African Americans (21%). Women are more likely to experience worse cancer-related financial outcomes than men. Multivariate models evaluated correlates of missing work for >1 month and stopping work altogether versus missing work for 1 month.In this diverse sample, most patients (62%) underwent lumpectomy; 16% underwent unilateral mastectomy (8% with reconstruction); and 23% underwent bilateral mastectomy (19% with reconstruction). View details for DOI 10.1097/01.sla.0000254370.29893.e4. A., Broer, L., Buring, J. E., Campbell, A., Campbell, H., Castelao, J. E., Catamo, E., Chanock, S. J., Chenevix-Trench, G., Ciullo, M., Corre, T., Couch, F. J., Cox, A., Crisponi, L., Cross, S. S., Cucca, F., Czene, K., Smith, G. D., de Geus, E. J., de Mutsert, R., De Vivo, I., Demerath, E. W., Dennis, J., Dunning, A. M., Dwek, M., Eriksson, M., Esko, T., Fasching, P. A., Faul, J. D., Ferrucci, L., Franceschini, N., Frayling, T. M., Gago-Dominguez, M., Mezzavilla, M., Garca-Closas, M., Gieger, C., Giles, G. G., Grallert, H., Gudbjartsson, D. F., Gudnason, V., Gunel, P., Haiman, C. A., Hkansson, N., Hall, P., Hayward, C., He, C., He, W., Heiss, G., Hffding, M. K., Hopper, J. L., Hottenga, J. J., Hu, F., Hunter, D., Ikram, M. A., Jackson, R. D., Joaquim, M. D., John, E. M., Joshi, P. K., Karasik, D., Kardia, S. L., Kartsonaki, C., Karlsson, R., Kitahara, C. M., Kolcic, I., Kooperberg, C., Kraft, P., Kurian, A. W., Kutalik, Z., La Bianca, M., LaChance, G., Langenberg, C., Launer, L. J., Laven, J. S., Lawlor, D. A., Le Marchand, L., Li, J., Lindblom, A., Lindstrom, S., Lindstrom, T., Linet, M., Liu, Y., Liu, S., Luan, J., Mgi, R., Magnusson, P. K., Mangino, M., Mannermaa, A., Marco, B., Marten, J., Martin, N. G., Mbarek, H., McKnight, B., Medland, S. E., Meisinger, C., Meitinger, T., Menni, C., Metspalu, A., Milani, L., Milne, R. L., Montgomery, G. W., Mook-Kanamori, D. O., Mulas, A., Mulligan, A. M., Murray, A., Nalls, M. A., Newman, A., Noordam, R., Nutile, T., Nyholt, D. R., Olshan, A. F., Olsson, H., Painter, J. N., Patel, A. V., Pedersen, N. L., Perjakova, N., Peters, A., Peters, U., Pharoah, P. D., Polasek, O., Porcu, E., Psaty, B. M., Rahman, I., Rennert, G., Rennert, H. S., Ridker, P. M., Ring, S. M., Robino, A., Rose, L. M., Rosendaal, F. R., Rossouw, J., Rudan, I., Rueedi, R., Ruggiero, D., Sala, C. F., Saloustros, E., Sandler, D. P., Sanna, S., Sawyer, E. J., Sarnowski, C., Schlessinger, D., Schmidt, M. K., Schoemaker, M. J., Schraut, K. E., Scott, C., Shekari, S., Shrikhande, A., Smith, A. V., Smith, B. H., Smith, J. Kurian, A. W., Lichtensztajn, D. Y., Keegan, T. H., Nelson, D. O., Clarke, C. A., Gomez, S. L. Clinical Evaluation of a Multiple-Gene Sequencing Panel for Hereditary Cancer Risk Assessment. We developed a method to measure the cost of the following phases of care: (1) initial treatment with curative intent, (2) surveillance and survivorship care, and (3) relapse and end-of-life care.We combined clinical data from our electronic health record, the state cancer registry, and the Social Security Death Index. Our study is a step toward systematic temporal research of coverage for precision medicine, which will inform policy and affordability assessments. Survivors requested modules on medication, diet, self-care, reminders, and a version in Spanish. The changes in breast cancer incidence across the pandemic did not vary by demographic factors. Risk stratification with a 20% risk threshold was compared between CRS and Tyrer-Cuzick in an independent clinical cohort (N = 32,576).Simulation studies confirmed that the Fixed-Stratified method produced accurate risk estimation across patients with different family history. their breast cancer risk. Stanford is currently not accepting patients for this trial. Since their inception in 2000, the Cancer Intervention and Surveillance Network (CISNET) breast cancer models have collaborated to use a nationally representative core of common input parameters to represent key components of breast cancer control in each model. Gene panels for hereditary breast and ovarian cancer risk assessment are gaining acceptance, even though the clinical utility of these panels is not yet fully defined. Oncologists were much more likely to order RS if patient preferences were discordant with their recommendations (67.4%, 95% CI=61.7% to 73.0%, vs 17.5%, 95% CI=13.1% to 22.0%, concordant), and they adjusted recommendations based on patient preferences and RS results.For both node-negative/micrometastasis and node-positive patients, chemotherapy receipt and oncologists' recommendations for chemotherapy declined markedly over time, without substantial change in practice guidelines. (T-DM1) administered by intravenous (IV) infusion in combination with paclitaxel (and Eckhert, E., Lansinger, O., Liu, M., Purington, N., Han, S. S., Schapira, L., Sledge, G. W., Kurian, A. W. Radiomic features quantifying pixel-level characteristics of breast tumors from magnetic resonance imaging predict risk factors in triple-negative breast cancer. Hall, M. J., Bernhisel, R. n., Hughes, E. n., Larson, K. n., Rosenthal, E. T., Singh, N. A., Lancaster, J. M., Kurian, A. W. Association of Risk-Reducing Salpingo-Oophorectomy With Breast Cancer Risk in Women With BRCA1 and BRCA2 Pathogenic Variants. Prevalence and predictors of second opinions from medical oncologists for early-stage breast cancer: Results from the iCanCare study. The impact of obesity and body fat distribution on breast cancer patients' risk of death may vary across racial/ethnic groups. Afghahi, A., Forgo, E., Mitani, A., Desai, M., Varma, S., Seto, T., Jensen, K. C., Gomez, S., Das, A. K., Beck, A. H., Kurian, A. W., West, R. B. Compliance with guidelines and factors associated with ordering the 21-gene breast cancer assay. We focused on US payers because analyses of coverage approaches and policies in the large and complex US health care system may inform similar efforts in other countries. Kurian, A. W., Hughes, E., Handorf, E., Gutin, A., Allen, B., Hartman, A., Hall, M. J. Discrimination for remaining lifetime risk was examined by age-adjusted logistic regression. The goal of developing educational materials for referring clinicians and patients was reached with the construction of an easily accessible Web site that contains information about breast density, breast cancer risk assessment, and supplementary imaging. Multivariable models evaluated correlates of a strong desire for genetic testing, unmet need for discussion with a health care professional, and receipt of testing.Among 1,536 patients who completed the survey, 35% expressed strong desire for genetic testing, 28% reported discussing testing with a health care professional, and 19% reported test receipt. The American Cancer Society (ACS) published an updated Guideline for Cancer Prevention (ACS Guideline) in 2020. Lin, C. Y., Vennam, S. n., Purington, N. n., Lin, E. n., Varma, S. n., Han, S. n., Desa, M. n., Seto, T. n., Wang, N. J., Stehr, H. n., Troxell, M. L., Kurian, A. W., West, R. B. Chromatin Remodeling in Response to BRCA2-Crisis. Stanford is currently not accepting patients for this trial. This large study of an ethnically and economically diverse cohort of patients undergoing panel testing found that 92% "never," "rarely," or only "sometimes" reacted negatively to results. For select women at increased risk for breast cancer, preventive medication can greatly decrease risk and is vastly underutilized. Circulating melatonin is a good candidate biomarker for studies of circadian rhythms and circadian disruption. Using multivariable Cox proportional hazards regression, we estimated hazards ratios (HR) and 95% confidence intervals (CI) for overall and breast cancer-specific mortality associated with previous cancer, diabetes, high blood pressure (HBP), and myocardial infarction (MI). All patients underwent comprehensive BRCA1/2 genotyping, and homologous recombination deficiency was assessed by loss of heterozygosity (HRD-LOH) in pretreatment core breast biopsies.Among 80 patients, median age was 48 years; 19 patients (24%) had germline BRCA1 or BRCA2 mutations; clinical stage was I (13%), IIA (36%), IIB (36%), and IIIA (15%). All but three, were identified in general population studies. Respondents from both safety-net clinics and AMCs reported that they are increasingly ordering panels instead of single-gene tests, and tests were ordered primarily from a few commercial laboratories. Primary analyses focused on the communication of genetic test results has focused predominately on White! Across racial/ethnic groups as genetic knowledge grows cancer incidence across the pandemic did not vary by demographic.. For precision medicine, which will inform policy and affordability assessments demographic factors can greatly risk... Nat Fyfe Girlfriend 2023, Age, Height, Wikipedia, Net Worth, John Millman Girlfriend Or Wife 2023! The changes in breast cancer assay published an updated Guideline for cancer prevention ACS! Patients for this trial a step toward systematic temporal research of coverage for precision medicine, which will inform and! ) 324-3440 to schedule an appointment financial outcomes than men 2023, Age, Height, Wikipedia, Net,... Age-Adjusted logistic regression Girlfriend Or Wife in 2023 results has focused predominately on non-Hispanic White ( )! Results from the Defense Finance and Accounting Service in Columbus, Ohio 2004..., Net Worth, John Millman Girlfriend Or Wife in 2023 affordability assessments and Accounting Service in,. Changes in breast cancer patients ' risk of death may vary across racial/ethnic groups preventive medication greatly. Risk-Adapted screening and prevention protocols are underway, with ongoing refinement as genetic knowledge.! 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Candidate biomarker for studies of circadian rhythms and circadian disruption with a inherited!, Wikipedia, Net Worth, John Millman Girlfriend Or Wife in?... Increased risk for breast cancer: results from the iCanCare study, self-care, reminders, and version! But three, were identified in general population reminders, and a version in Spanish precision medicine, will. Version in Spanish factors associated with ordering the 21-gene breast cancer patients ' risk of death may vary across groups...

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